(TC79) Endodontic Surgery and Platelet Concentrates: A Review of Regenerative Applications

Objective(s)

This review evaluates autologous platelet concentrates (APCs) in endodontic microsurgery (EMS) to enhance periapical lesion healing. Despite APCs’ regenerative potential, their effectiveness varies. The study aims to assess APC impacts on healing, pain management, and quality of life.

Methods

A literature review was conducted on APCs like platelet-rich plasma (PRP) and leukocyte platelet-rich fibrin (L-PRF) in EMS, focusing on clinical outcomes, healing rates, postoperative pain, and quality of life. Articles were sourced from databases like PubMed, with statistical analysis on lesion reduction and P-values.

Results

APCs, notably PRP and L-PRF, reduced lesion sizes and improved postoperative comfort. PRP showed a significant lesion volume reduction (92.3%) in complex lesions. However, outcomes varied by application protocols, with L-PRF improving early healing in apical-marginal defects without significant long-term radiographic differences.

Conclusion

APCs show promise for enhancing EMS outcomes and reducing recovery time and postoperative discomfort. Further studies are needed to standardize APC protocols in endodontics and confirm their efficacy in controlled trials.