(PR123) Long-Term Outcomes of Regenerative Endodontic Procedures: A Retrospective Analysis

Objective: This study investigates the long-term outcomes of regenerative endodontic procedures (REPs) performed at the Postgraduate Endodontic Clinic at the University of Pennsylvania School of Dental Medicine (PDM).

Methods: A retrospective analysis was conducted on 54 patients who underwent REPs at PDM from 2017 to 2020. Follow-up data were available for 11 of these patients. Treatment success was determined based on clinical and radiographic stability, defined as the absence of symptoms and normal responses on percussion, palpation, and mobility tests. Radiographic criteria for success included healing of any periapical lesions, evidence of continued root development, and apex closure. Treatment failures were identified in cases requiring retreatment or exhibiting persistent symptoms.

Results: Among the 11 patients available for follow-up, five demonstrated successful outcomes, while six exhibited treatment failures. All successful cases were associated with well-sealed permanent restorations or crowns, whereas all failures involved compromised restorations, evidenced by marginal leakage or recurrent decay.

Conclusion: The findings indicate that successful long-term outcomes in REPs are strongly associated with high-quality, well-sealed permanent restorations. In contrast, treatment failures were often related to compromised restorations, such as those with recurrent decay or leakage. These results highlight the importance of restoration quality in achieving long-term endodontic success and suggest that restorative protocols following REPs may warrant further optimization.